| All prices are in Canadian dollars | |
|---|---|
| Limited special offer: | $64.95/bottle |
| 5 to 9 bottles: | $62.95/bottle |
| 10 or more bottles: | $59.95/bottle |
| Free shipping for 5 bottles or more | |
MGN-3 Immunotherapy For The Treatment Of Cancer
Ghoneum M. Maeda H. Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, USA and Daiwa Pharmaceutical Co., Ltd. Tokyo, Japan
The main substances of MGN-3 is an activated Arabinoxylane compounds.
MGN-3 has been shown to be a powerful biological response modifier (BRM) as manifested by remarkable increase in natural killer (NK) cell activity in Immunocompromised individuals.
In the present study, we evaluated the immunomodulatory function of MGN-3 in 10 patients with different types of advanced malignancies.
These subjects include:
- 1 patient with squamous cell carcinoma (lingual)
- 1 lung
- 1 esophageal
- 1 stomach
- 1 rhabdomyosarcoma
- 1 brain
- 1 liver
- 1 ovarian
- 1 colon and
- 1 testicular
Patients were under conventional therapy before participating in the study. Patients received MGN-3 at concentration of 45mg/kg/d orally for 2-6 months. Parameters under investigation included: NK cell activity against K562 tumor target cells. NK cell subpopulations using flow cytometry; and T and B cell functions. Patients were examined for these parameters at 0 day (baseline) and at 2 wks post treatment with MGN-3. Patients showed significant increase in NK activity ( more 2 fold) at 2 wks as compared to baseline value, while there was no change in NK cell populations. Patients also demonstrated elevation of T and B cell function as demonstrated by their proliferation response to different mitogens. The mechanism by which MGN-3 exerts its augmentory effect was examined and appears to be due to the production of cytokines such as TNF-α and IFN-Υ.
We conclude that MGN-3 is a potent BRM and in the absence of notable side effects, MGN-3 may be useful in the immunotherapy of cancer.