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Immunostimulation and Cancer Prevention
Mamdooh Ghoneum , Chief, Research Department, Charles Drew University, Los Angeles, California USA
Several studies have established the excessive cancer risk for workers exposed to several widespread workplace chemicals. The present study was designed to examine the immune alteration associated with exposure to toxic chemicals and possible counteracting of chemical toxicity using BioBran/MGN-3. 11 individuals who had been exposed to chemicals in the workplace participated in the study. The participants demonstrated immune dysfunction as indicated by: low levels of natural killer (NK) cell activity (10.2+4.2LUs). Subjects received BioBran/MGN-3 at a dose of 15mg/kg/d for 4 months. Treatment with BioBran/MGN-3 increased NK cell activity 4 and 7 fold at two and four months respectively, while T and B-cell functions were 130-150% higher than base line values.
We conclude that suppression in NK activity by chemical exposure can fully restored with BioBran/MGN-3.
The effect of stress during human NK cell immunomodulation by BioBran/MGN-3 is worth investigation, since stress in known to be a strong immune depressant.
During the course of treatment with BioBran/MGN-3, 11.6% of the responders (10/86) suffered from different kind of stressors, such as: sleep deprivation, bereavement following the loss of a spouse of close relative, work overload or financial problems.
These patients evidence 40-75% decrease in their NK activity as compared to the previous level.
After elimination of some stressors, the NK activity increased back to the former value.
Our preliminary results suggest that stress cause immune suppression during the course of BioBran/MGN-3 treatment.
Monitoring NK activity on a monthly basis will be able to detect this suppression which requires correction, otherwise it will have definite future clinical ramifications.